# Kisspeptin studies, in company

> Real TRT reading list — The Real TRT reading list: published kisspeptin papers on discovery, testosterone, hormone responsiveness, repeated exposure and sexual desire.

**Reading list**

The early response is more interesting with the later experiments beside it.

## Testosterone and responsiveness

The [early healthy-men experiment](https://pubmed.ncbi.nlm.nih.gov/16174713/) and the [kisspeptin-10 pulse study](https://pubmed.ncbi.nlm.nih.gov/21632807/) are the natural starting pair for the testosterone question. I would then put the [nonresponsive hypogonadism cohort](https://pubmed.ncbi.nlm.nih.gov/25226293/) beside the [men studied after reversal](https://pubmed.ncbi.nlm.nih.gov/27214398/). The contrast in responsiveness gives the attractive initial finding a much more interesting setting.

For the earlier history, the [KISS1 melanoma paper](https://pubmed.ncbi.nlm.nih.gov/8944003/), [puberty genetics](https://pubmed.ncbi.nlm.nih.gov/14573733/) and [animal work on GnRH release](https://pubmed.ncbi.nlm.nih.gov/15665093/) belong in the same conversation, with their different populations and experimental models intact.

## Receptor and brain studies

Removing the [repeated-exposure study](https://pubmed.ncbi.nlm.nih.gov/19820030/) would make this collection much less useful to me. Read it alongside the [continuous-infusion experiment](https://pubmed.ncbi.nlm.nih.gov/24517142/) and the [receptor pharmacology review](https://pubmed.ncbi.nlm.nih.gov/25765628/). The [intranasal study](https://pubmed.ncbi.nlm.nih.gov/40215751/) asks a separate question about delivery.

For desire, the [male randomized trial](https://pubmed.ncbi.nlm.nih.gov/36735255/) and [attraction-cue imaging study](https://pubmed.ncbi.nlm.nih.gov/32051344/) sit well beside the [anxiety trial](https://pubmed.ncbi.nlm.nih.gov/40036336/). The [sexual-dysfunction review](https://pubmed.ncbi.nlm.nih.gov/40189467/) discusses the psychosexual prospects, while the [systematic review of clinical status](https://pubmed.ncbi.nlm.nih.gov/38265397/) surveys the broader reproductive applications. Their conclusions have the dates and search limits of the publications themselves.

## References

[1] KiSS-1, a novel human malignant melanoma metastasis-suppressor gene https://pubmed.ncbi.nlm.nih.gov/8944003/
[2] The GPR54 gene as a regulator of puberty https://pubmed.ncbi.nlm.nih.gov/14573733/
[3] Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 https://pubmed.ncbi.nlm.nih.gov/15665093/
[4] Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males https://pubmed.ncbi.nlm.nih.gov/16174713/
[5] Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men https://pubmed.ncbi.nlm.nih.gov/21632807/
[6] Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism https://pubmed.ncbi.nlm.nih.gov/25226293/
[7] Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty https://pubmed.ncbi.nlm.nih.gov/27214398/
[8] Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis https://pubmed.ncbi.nlm.nih.gov/19820030/
[9] Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54 https://pubmed.ncbi.nlm.nih.gov/24517142/
[10] KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis https://pubmed.ncbi.nlm.nih.gov/25765628/
[11] Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/36735255/
[12] Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men https://pubmed.ncbi.nlm.nih.gov/32051344/
[13] Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans https://pubmed.ncbi.nlm.nih.gov/40036336/
[14] Kisspeptin and its current clinical status - a systematic review https://pubmed.ncbi.nlm.nih.gov/38265397/
[15] Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans https://pubmed.ncbi.nlm.nih.gov/40215751/
[16] Can kisspeptin be a new treatment for sexual dysfunction? https://pubmed.ncbi.nlm.nih.gov/40189467/

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At Real TRT I scrutinise published research on kisspeptin and testosterone; this is an editorial site rather than a treatment business, and none of it is medical advice.