Kisspeptin studies, in company
The early response is more interesting with the later experiments beside it.
Testosterone and responsiveness
The early healthy-men experiment and the kisspeptin-10 pulse study are the natural starting pair for the testosterone question. I would then put the nonresponsive hypogonadism cohort beside the men studied after reversal. The contrast in responsiveness gives the attractive initial finding a much more interesting setting.
For the earlier history, the KISS1 melanoma paper, puberty genetics and animal work on GnRH release belong in the same conversation, with their different populations and experimental models intact.
Receptor and brain studies
Removing the repeated-exposure study would make this collection much less useful to me. Read it alongside the continuous-infusion experiment and the receptor pharmacology review. The intranasal study asks a separate question about delivery.
For desire, the male randomized trial and attraction-cue imaging study sit well beside the anxiety trial. The sexual-dysfunction review discusses the psychosexual prospects, while the systematic review of clinical status surveys the broader reproductive applications. Their conclusions have the dates and search limits of the publications themselves.
- KiSS-1, a novel human malignant melanoma metastasis-suppressor gene ↗
- The GPR54 gene as a regulator of puberty ↗
- Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 ↗
- Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males ↗
- Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men ↗
- Exogenous kisspeptin administration as a probe of GnRH neuronal function in patients with idiopathic hypogonadotropic hypogonadism ↗
- Kisspeptin Responsiveness Signals Emergence of Reproductive Endocrine Activity: Implications for Human Puberty ↗
- Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis ↗
- Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54 ↗
- KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis ↗
- Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial ↗
- Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men ↗
- Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans ↗
- Kisspeptin and its current clinical status - a systematic review ↗
- Intranasal kisspeptin administration rapidly stimulates gonadotropin release in humans ↗
- Can kisspeptin be a new treatment for sexual dysfunction? ↗